I recovered fully within weeks after I transitioned to full T3 monotherapy. Many doctors are still very uncomfortable with this as they mistakenly think that the lab ranges developed for people on T4 meds can be used for ALL the thyroid medications. In I tried to reintroduce T4 hormone. Thyroxine Products. Legs and arms lose some muscle mass.
It is really hard for me to discuss specific patient situations via this website.
I spent a treatment for hypothyroidism of years reading them and it was pretty obvious, straight away, that my theory was that I didn't have the same level of T3 after being on thyroxine that I had before. You can read more about my own personal health journey and why I am so passionate about what I do here.
As you can see the end of the day I take a lot of T3 in a few hours time. Share on Twitter Twitter.
This is especially encouraging in cases where patients have been pushed too far in the wrong direction with the wrong medicine.
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See our levothyroxine dosage chart below to get an idea of where your treatment might begin and when to expect your doctor to check for adjustments. The Journal of Clinical Endocrinology and Metabolism, 96 11— The impact of thyroid hormone dysfunction on ischemic heart disease.
Just started this test. The Competition and Markets Authority the competition watchdog has investigated and is due to report yreatment. T3 only treatment for hypothyroidism always vary with the type of assay that they do when they test thyroid hormones. Share on Linkedin Linkedin. All the other results hardly moved their levels within the normal reference range. Table of Contents. When thyroid hormone is used to treat hypothyroidism, the goal of treatment is to keep thyroid function within the same range as people without thyroid problems.
Yeah, go ahead, Paul. People diagnosed as hypothyroid who are taking T4-containing medicine may never have been hypothyroid, or if they were, may not be now. T3 therapy can be used as symptomatic, therapeutic, or prophylactic treatment. And the best book to start with probably is my more general one, called The Thyroid Patient's Manual. I read endocrinology books — real ones that are used during medical training. Sorry jlynx that you haven't had better luck. I was totally healthy prior to this point.
Renew the paradigm. Optimize our therapy.
If you are a rare person like me, living without any T4 hormone, you have to get all your T3 from dosing thyroid hormone medication instead of gradual T4-T3 t3 only treatment for hypothyroidism. Antacids and the cholesterol-lowering drugs Colestid colestipol and Questran cholestyramine can interfere with the absorption of Cytomel. Problems like tiredness, body aches, depression and weight gain did not improve significantly. Journal of Endocrinological Investigation, 6 6— In the human body, the biological half-life of T4 is approximately seven days, which means a patient can take their entire daily dosage of synthetic T4 in one go, without any issues, because it is used up relatively slowly.
I felt better when my T4 was raised but as this dropped my TSH below range I remained poorly medicated. While most actions of thyroid hormone are most likely due to T3, most T3 in the body comes from the conversion of T4. Mugesh, n. Issue Autumn
FT3 was 8. For example, if a patient presented on. Have you had success with any similar protocols? Had surgery to remove my gland.
J Clin Endocrinol Metab ; — Article Sources. The duration of suppression therapy in cancer patients is currently being debated. Levothyroxine is the name of all synthetic forms of the thyroid hormone T4. Keep in mind, though, that this side effect is rare.
Is there ever a reason to add T3 to NDT (natural desiccated thyroid)?
Paul Robinson: Yeah. Friedman's Guide To Weight Loss. The endos should be looking at, "Okay, well, we're going to need to drop that levo and we're going to need to really get that T3 up.
If in the top of the range, one still has hypo symptoms, that high Hyptohyroidism T3 could represent pooling —the latter for hypothyroidism to a cortisol problem. Someone new to T3 replacement therapy may believe that the medication can be taken in a single daily dose, just like synthetic T4. So I got the books. So I'm off work. That's a lot of T3, and most endocrinologists would freak out at that.
A symptom is a subjective assessment of something. I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. It is worth emphasizing the degree of progress that is often made during the 10 day period. Most patients with hypothyroidism are treated with T 4and their doctors assume that it gets converted to T 3 physiologically. CW1 maybe the issue is your adrenals are exhausted, which is why you were only able to tolerate the t3 for a bit. Think you may have a cortisol problem? Far more people are able to stay comfortably off all thyroid for the 10 days than you might expect.
Since TSH has come out life has been hard. Attempting to use thyroid labs is likely to result in the thyroid patient remaining hypothyroid. For many patients this happens, and many patients do well on T 4 -alone treatment. Just a broad range here.
If you are hypothyroid and want to take advantage of Dr. Some would always get through, I guess.
CW1 Yes, T3 does work quickly so you could have those feelings.
Patients that are using T3 on its own will certainly struggle to get any value at all from thyroid blood test results.
Like this post? I always have to make sure I get enough T3, and never too much for hypogonadism primary success stories body, and I have to make sure that I never, ever run out of T3 pills. Thyroid scientists have discovered that the human body can handle very wide daily fluctuations above the normal Free T3 range without tissues becoming thyrotoxic. How Hypothyroidism Is Treated.
Muscle weakness. So imagine the people that have hypothyriodism virtually no thyroid function, it shut down, they've either had a thyroidectomy or they've had Hashimoto's for a long time. It's the only one that binds the receptors in the cell nucleus. Body temperature. Therefore, in patients only on T 3the level of thyroid hormone in the brain might be quite low.
What place does it have in thyroid disease treatment?
My preferred dose is 40mcgs of t3 and 50mcgs of t4. Hypothyroidiism that are using T3 on its own will certainly struggle to get any value at all from thyroid blood test results. What if the patient improves at first, but then stops feeling as well even though the temperature is holding?
You take "natural" thyroid medications and supplements. Endocrine Reviews, 40 4— Will of course contact Doc 2 also. Since my late 20s, I spent many more years being habituated to being hypothyroid than being truly euthyroid. Autumn From genetics to therapeutics: Thyroid covered. Best wishes, Paul Updated in May
In another Italian study, coffee interfered with absorption. In a fragile health context, a chronic low er T3 is a major health vulnerability. I can generalize one thing about people on T3 monotherapy: By the time we get to this last resort, it is almost always the only thing or best thing that helped, and we will get sick again if we try to move back toward a combination of T4-T3 dosing. If it does occur, it can usually be easily fixed with a dose adjustment.
Save my name, email, and website in this browser for the next time I comment. Heart rate's normal. Tried twice now - it makes me wired then later I crash and become weak and nauseous. I agree with you. The Endo also said I either have central hypothyroidism or a pituitary gland that is not functioning properly but as the treatment is the same it was irrelevant which was the cause. However, be careful because some patients having been told this will stay off all T3 for the 10 days in spite of worsening, to the point of having a hard time with normal daily functioning. Paul Robinson: Wow.
I'm feeling a touch of uncomfortable jitteriness - it's not horrible but noticeable. How high up on the medicine does one go on each cycle of T3 therapy? They'll be taking 75 mics of levothyroxine and five mics of Cytomel, let's say.
Thyroid Cancer Guide. Our thyroid-friendly meal plan can help. It has enough background information on T3 and a protocol for using T3 only. Table of Contents. Plus, I have an atrophied thyroid, now known to be caused by TSH-Receptor blocking antibodiesand these antibodies act directly on the pituitary and can make TSH fluctuate high in ways that contradict the FT4 level. Why this combination? The dose will then need to be adjusted by a physician to keep the thyroid function normal.
Given these observations, some might wonder if it would be better to leave hypothyroid patients on T3 therapy, rather than to put treatment for hypothyroidism back on T4. A few patients find that they can cope with only two divided doses. I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. It's very searchable and there's a great blog there and there's a little spyglass in the top and they can search for any topics. T3 therapy can be used as symptomatic, therapeutic, or prophylactic treatment. Since TSH has come out life has been hard. The doctor doesn't know what it's like to live day-to-day like you are living.
Combination treatments of L-T3 and L-T4 should only be initiated and supervised by accredited endocrinologists. T3 is considered the active form of thyroid hormone. Bianco, A. Mirell, C. Their role is to regulate metabolism the conversion of oxygen and calories into energy. I like half the T3 first thing in the morning, then hours late sneak in the t4, then evening the other half of the T3. I eventually have body-wide shivering episodes in a normal temperature room and have to get a sweater and turn on a space heater.
A HISTORICAL PERSPECTIVE
Share on Linkedin Linkedin. But not everyone can tolerate T3 at bedtime keeps them awakeso they have to experiment. Hypothyroidism causes cardiovascular disease.
T3 only treatment for hypothyroidism can take up to weeks sometimes less for the high RT3 to fully fall, patients have noticed, and anywhere during that lowering process, patients report suddenly feeling a little hyper as the T3 comes up and is better able to reach good cellular levels which the excess RT3 prevented. That sounds about right. I've got a tendency to think we should have different lab ranges for different types of medication. CW1 Sep 3, Paul Robinson on 30th August at am.
You bet. Levothyroxine dosage is highly individualized, and your dosage may change hypothyroidisj you and your doctor work to find what works best for you. If you are a rare person like me, living without any T4 hormone, you have to get all your T3 from dosing thyroid hormone medication instead of gradual T4-T3 conversion. Number 5 T3-Only is harder to use than the others.
Plus, how to get the absolute most out of your thyroid meds
Glad to know the t3 and glandulars helped. I felt better when my T4 was raised but as this dropped my TSH below range I remained poorly medicated. Had hyper-like symptoms when raising T3?
Think you may have a cortisol problem? I can't handle the adrenal cortex though. So let's start there then, because I know that if anybody who knows you, they know that that's clearly not the end of your story, right, because levothyroxine, I think it's Euthyrox is the common version in the UK, right? Work with your doctor.
My typical thyroid blood test results back in looked like this on my 60 micrograms or so of T3 hypothyoidism for hypothyroidism — which is quite a modest amount compared to some patients : TSH is often near zero but if I leave a gap of 18 hours or more between my last T3 dose and the blood draw, I can make TSH higher. So you're talking basically about the two major things that an endocrinologist will say. Signs: Resting heart rate. It should be three or four. CW1 Sep 16, I know.
THYROID HORMONE TREATMENT
Share on Facebook Facebook. Natural desiccated thyroid NDT. Some alternative doctors are very concerned with keeping the reverse T 3 quite low and sometimes use only T 3 to lower it. Your brain is not processing the input properly. As I went from
The existing porcine thyroid extracts were far from physiological, as the pig thyroid produces thyroxine T4 and tri-iodothyronine T3 at a ratio ofcompared with the ratio of in human thyroid. Different rates of thyrotropin suppression after total body scan in patients with thyroid cancer: Effect of an optimal saturation regimen with thyroxine or triiodothyronine. It seemed as if there was a glass ceiling above which FT3 could not rise when a certain amount of FT4 in blood shifted my deiodinase activity in a dysfunctional way. Why should I say this last statement? Many doctors are still very uncomfortable with this as they mistakenly think that the lab ranges developed for people on T4 meds can be used for ALL the thyroid medications. A type of heart arrhythmia called atrial fibrillation and bone loss osteoporosis may also occur. Of course I pay the price after I gradually, unnoticeably fade into a hypothyroid state within hours after the scheduled dose time and my brain slows down.
By starting the treatment in this manner, the patient can almost completely reverse in a matter of 3 weeks what has perhaps taken years treatnent develop, thereby giving the patient a virtually fresh start. So if your doctor throws you on A lot- Dr. I went through endocrinologists, several endocrinologists, and private ones, which I paid good money to. Westin Childs: Yeah. Many patients are now hungry for information about this under-prescribed thyroid medication.
My books cover a lot of this. However, I revised my hypothesis after I obtained more of my laboratory history going back to Table of Contents. Hyperthyroidism: What's the Difference?
DEFINITION, THERAPY & TREATMENT
Do temperatures or T4 test doses have to treatent taken to the minute like the T3? You are not going to get all of that FT3 usable. In addition, if cortisol remains low you might be a candidate for my CT3M protocol to attempt to raise cortisol. I've got a tendency to think we should have different lab ranges for different types of medication. So, finding the right balance of T4 and T3 can be an extremely challenging task.
Next, such a pharmaceutical estimate does not take into account the fact that deiodinase enzymes shift their roles and interact very differently in the context of T3-only therapy. Infographic by Lauren Hunter. Louzada, R. EJ Cavaliere, H.
I concluded that a trial of T3 Liothyronine was necessary because my hypothyroidism was not fixed by using Levothyroxine T4.
If in the top of the range, one still has hypo symptoms, that high Free T3 could represent pooling —the latter due to a cortisol problem. Also, if patients relapse when they are on.
Indeed, it is very important for pregnant women, or women who are planning to become pregnant, to have normal thyroid function to provide the optimum environment for her baby. Triac is active in the T3 receptor, but Triac has a much shorter half-life than T3.
Why should I say this last statement?
His research shows when studying individuals, a large number of individuals, and working out what dose they need to be on and what their FT3 or FT4 level needs to be, he's found out that, basically, most people need to be in a space within that lab range which is less than half as wide as the population range. And yet, and often, often, because their TSH is low, their doctor is dropping their thyroid meds and making them sicker again. It's not relevant. I do not take glandulars as I could not tolerate them stomach pain but I do go to a medical herbalist who has me on liquorice amongst other things that help support.
So she tested all that, and the next thing I knew is I had a That is horrible about the medication price change! None of these treatments made a bit of difference. Additionally, other symptoms of adrenal stress such as anxiety, insomnia, and palpitations racing heart can then occur.
THE USE OF COMBINATION THERAPY
First of all, what trsatment they basing the equivalence on? MyT3 is 24 mcg waking am7 mcg 10 am, 7mcg 1pm, mcg 2pm, 12 mcg 3pm, 25 mcg pm, and NDT at 4pm. Synthetic forms of L-T4, available since the s, were introduced without any consideration of the need for randomised controlled trials. I have read all the scientific publications I can find about people maintained on both short-term and long-term T3 monotherapy, and they are a treasure.
I need much more Free T3 flowing through my blood than normal people who have a normal amount of Free T4 in blood alongside their Free T3.
Paul Robinson Paul Robinson is a British author and thyroid patient advocate.
Email Required Name Required Website. Also, I wondered if T4 does anything else other than convert to T3.
So I've worked with probably well over 1, people on T3 for that time. Yeah, at this point I'm not expecting any treatment to be THE answer
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Natural thyroid supplements may contain gland tissue from the thyroid, liver, heart, t3 only treatment for hypothyroidism and other animal organs of dor a tiny but serious risk for exposure to prions— agents that could transmit the brain disease Creutzfeldt—Jakob. Legs and arms lose some muscle mass. But I would not have it any other way. Adding T3 should be considered in people who continue to have symptoms of hypothyroidism, and whose T3 levels remain in the low end of the normal range.
Absolute rubbish. The endos should be looking at, "Okay, well, we're going to need to drop t3 only treatment for hypothyroidism levo and we're going to need to really get that T3 up. So this is a long, long time ago, in a galaxy far away, okay? Are they actually hyperthyroid? I think we probably both agree with that. His three books cover all of this.
Volume 24, Number 12, As you can see the end of the day I take a lot of T3 in a few hours time. Most people like me without cortisol problems can eventually onlu larger doses of fast-release T3 without any jarring cardiovascular response. Hyperthyroidism: What's the Difference? Next, such a pharmaceutical estimate does not take into account the fact that deiodinase enzymes shift their roles and interact very differently in the context of T3-only therapy. The details of my laboratory data and the scientific publications that support the hypothesis will have to wait for future posts. Inhibition of thyrotropin response to thyrotropin-releasing hormone by small quantities of thyroid hormones.
GENERAL INFO ABOUT T3 MEDICATION
This is what I have done for well over twenty years. I mean, when I was looking at this study, it was talking about the average length of time that thyroid patients have symptoms before they try to seek other help, and it's on the order of 10 years, 5 to 10 years. Childs, and that's if they'd been put on five micrograms, and you've said it yourself earlier today, that five micrograms of T3 tends to suppress TSH a little bit more than T4, the TSH is basically involved in the regulation of the deiodinase enzymes that convert T4 to T3. What are the substantive risks of T3 therapy? You get it in brands like Cytomel.
As I went from
Thank you guys the input! Yeah, go ahead, Paul.
However, a safe and effective protocol needs to be used — this is why I wrote Recovering with T3.
T3 level unsteadiness can result in decreased clinical improvement, before it results in side effects. What do you think about the role of reverse T3 in relation to free T3?
In addition, if cortisol remains low you might be a candidate for my CT3M protocol to attempt to raise cortisol. For many people with hypothyroidism, this is enough to get their thyroid hormone levels back in the ideal range.
Paul Robinson: Well, that took me 10 years. My TSH is normal, but my T3 is still low.
Yet other products can prevent the absorption of the full dose of thyroid hormone. July 13, Leave a public reply here, on our website. An Overview of Thyroid Disease Treatments.
Patients should be reminded and reassured that should they worsen at all clinically during the weaning process, before T3 therapy is used to chase the temperature, that the T3 can be started to support ojly if needed. Patients that are using T3 on its own will certainly struggle to get any value at all from thyroid blood test results. Some might be using mostly T3 to help lower high Reverse T3the inactive hormone. When this occurs, the levels of hormones within the bloodstream are likely to be completely unrepresentative of the cellular activity of the T3. Last edited: Sep 2,
How we learned to start on T3 if using it alone
So, what is considered to be high will be dependent on the actual lab and the type of assay that they do. Next, hypothyroidosm a pharmaceutical estimate does not take into account the fact that deiodinase enzymes shift their roles and interact very differently in the context of T3-only therapy. I was struggling at night with cold feet, going to bed shivering and wearing leggings and socks. Thank you so much for this extremely informative and useful article about your journey to T-3 therapy!
Thyroxine Products. Vella, K.
I went through endocrinologists, several endocrinologists, and private ones, which I paid good money to.
Evidence appeared of potential harm from L-T4 over-replacement, including atrial fibrillation and bone loss, particularly in postmenopausal women.
Do you think it plays a role to help somebody clinically determine their dose? Your cart is empty Return to Shop. This type of presenting history and response to treatment is very common. It is also important to use symptoms and signs to determine when each T3 dose is due during the day — taking a T3 divided dose too early is just as bad as taking too much.
If it does occur, it can usually be easily fixed with a dose adjustment. Elephant in the Room Books. Article Sources. T3 only treatment for hypothyroidism was so little discussion about T3 and so few people who had good experiences of using it that I found the Internet forums to be quite difficult places to inhabit. But for others, it could take a month or two to feel better. Friedman has recently posted an article about using reverse T 3 and does find it useful in some patients.
My temperature's normal. The best treatment of severe side effects of T3 therapy is prevention, but… T3 levels that are too high, too hypothyrokdism, or unsteady can cause side effects. However I am in the UK where I am able to get my T3 for free at present, but due to massive price rises here on T3 due to manufacturers renaming a previously cheap drug and charging excessive prices to increase profitsI worry that I may end up needing to buy it on the net eventually if the NHS refuse to supply it to me, as some places have already. So in that case say, say they're almost right with a hundred micrograms of T4. I'm sick. Share on Pinterest Pinterest.
Why this combination? A very good site is ThyroidUK, I have received excellent information there. The conversion of T4 to T3 is normal in hypothyroid patients.
Several scientific studies have looked at whether T4 therapy would be of benefit to patients with symptoms that overlap with hypothyroid symptoms and normal thyroid function.
I used the emerging Internet resources. I have been all over the place w my reaction to it.
Updated January 15,
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The Journal of Clinical Endocrinology and Metabolism, 96 11— When I first began to discuss T3-Only use on forums many years ago, I frequently met ignorance, defensiveness, incredulity, and even abusive and rude comments from other thyroid patients.
Friedman recommends against this for several reasons. Cytomel or with slow release T3. My T3 is low. This may work for a few people but for others, the daily dosage of T3 will need to be split up and taken in smaller doses, known as divided doses.
To avoid this, always separate the doses of Cytomel and the other drugs by at least four hours. Right now, the best thing you can do for your thyroid care is to carefully talk through your options with your doctor. Hypohhyroidism Guide to Insulin The purpose of the Patient Guide to Insulin is to educate patients, parents, and caregivers about insulin treatment of diabetes. If a change in brand name is unavoidable, you should be sure your physician is aware of the change, so that your thyroid function can be rechecked. We can each have a complex, unpredictable, individual response to thyroid medication. For patients who are long established on L-T3 and are thought to be stable, a change to L-T4 monotherapy should not be implemented without careful discussion. The biological half-life is 2.
The genetic basis of congenital hypothyroidism. Bianco, Deiodinase Type 2 of course has no Uypothyroidism to deiodinate into intracellular T3 in this context, but it still functions to remove iodine from the outer ring of T3, turning it into T2. Thus, there is no indication for the use of T3 alone for the treatment of hypothyroidism. In addition to hypothyroidism, Cytomel is used for:.
Symptoms of hyperthyroidism include a fast heart rate, insomnia, and anxiety.
But the people that always do the best on the treatment are the ones that are lucky enough to get their temperatures up on the smallest levels of the medicine.
After surgery for thyroid cancer, thyroid hormone is needed both to replace the function of the removed thyroid gland and to keep any small or residual amounts of thyroid cancer cells from growing see Thyroid Cancer brochure.
I have no weight issues or any other symptoms of hypothyroidism or low cortisol. Westin Childs: Yeah.
Friedman recommends against this for several reasons. Once the nature of the T3 hormone is understood and the reasons why people resort to it are also taken into account, it should become clear why T3 is a medication that should be not be seen as a simple panacea. Why only around mid-range for free T4 or very slightly above? I have been all over the place w my reaction to it. Paul Robinson: Well, that took me 10 years. Do you think it plays a role to help somebody clinically determine their dose? Bella on 29th August at pm.
I hope so. It is not wise to stop the T3 medicine abruptly. So number one, I get the idea or T3 only treatment for hypothyroidism got the impression from thyroid patients who believe that no matter what dose of T3 you're taking, it will always cause TSH suppression or a low TSH. Paul Robinson Paul Robinson is a British author and thyroid patient advocate. Subsequent cycles are promising if there is a net clinical improvement from a previous cycle. Patients that are using T3 on its own will certainly struggle to get any value at all from thyroid blood test results. Search for:.
So let's do this though, Paul, I want to ask one more question. This is what I have done for well over twenty years. Whichever it is the dosage of the T4 medication might need to be lowered and the T3 increased until your symptoms resolve.
For most people with hypothyroidism, the body converts levothyroxine into sufficient T3.
Some eventually do well on twice a day as the tissues become saturated.
I agree with you. However, I revised my hypothesis after I obtained more of my laboratory history going back to
While you may be interested in trying a T3 drug, know that some doctors may recommend that you stick with levothyroxine alone, given that it is the standard of care for hypothyroidism per guidelines set forth by the American Association of Clinical Endocrinologist AACE and American Thyroid Association ATA. In general, my first symptom of hypothyroidism is cognitive slowdown, and it starts to happen even 5 hours after one of my 15mcg doses.
It is very common for people with low FT3 levels to have various pituitary issues, as the pituitary needs a lot of T3 to work properly.
Do you think it plays a role to help somebody clinically determine their dose? When weaning a cycle of T3 therapy, does one wean partway down, down to the starting dose, or all the way off? See this page. It's just non-existent there on your lab testing. So a lot of people perhaps watching this, they probably fall into that category where T3 would be beneficial, because as Paul was mentioning, a lot of the people who take T4 medication who are able to convert that T4 into T3, they're going to be probably fine right? So let's do this though, Paul, I want to ask one more question.
I agree with you. And there are lots of reasons for that. Google site search. It's linked to cancer. Yeah, go ahead, Paul. Log in.
None of these treatments made a bit of difference. I have now been using T3 Liothyronine for around 20 years and am fit and well. About us. Paul Robinson: I'm completely fine.
Labs always vary with the type of assay that they do when they test t3 only treatment for hypothyroidism hormones. Some day you or someone you love might need it. Indeed, it is very important for pregnant women, or women who are planning to become pregnant, to have normal thyroid function to provide the optimum environment for her baby. You store your levothyroxine tablets in the wrong place.
This is also good to share with your doctor. The BMR used to measure hyptohyroidism energy consumed by the body when completely at rest. A doctor who is not open-minded may not accept this. I was refused any more blood tests or referrals by one GP unless I took Prozac antidepressants for some time.
Lowering NDT will also slowly lower the conversion to T3. We can't give you T3, it's going to cause osteoporosis. But T4 is great. Paul Robinson: Anywhere in the range. And clinically just means how you're presenting, what you're feeling. And so I think what ends up happening is we have a lot of people who use T3, who end up with a TSH that's probably on the lower end.